Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer.

Although in univariate single-marker analyses EpCAM failed to reach statistical significance in our study cohort, multivariate results indicate that reduced EpCAM expression was, as hypothesised, associated with a worse DSS and higher recurrence rates in CRC.

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We are the first to show this association in a colon cancer patient cohort in multivariate survival analysis, as other studies did not reach statistical significance mostly due to low patients numbers ( Lugli et al , 2010 ; Kahlert et al , 2012 ).

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