Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding.

J Hematol Oncol · 2014 · PMC4059877 · PMID 24886876

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reached borderline significanceno p-value reported

In ALL risk genotypes were defined as ETV6 _rs1573613 CC, PML _rs9479 GG, TLX1 _rs2742038 TT, ATM _rs227091 CC and CT, and IRF8 _rs10514611 TT (the latter two reached borderline significance in the analysis of individual SNPs).

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a significant trendno p-value reported

Moreover, we observed a significant trend for an increasing ALL and CML risk with the growing number of risk genotypes with OR = 13.91 (4.38-44.11) for carriers of ≥3 risk genotypes in ALL and OR = 4.9 (1.27-18.85) for carriers of 2 risk genotypes in CML.

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borderline significantno p-value reported

The SNPs showing a significant or borderline significant (before applying FDR) association with leukemia risk were then analyzed for the effect of the total number of risk genotypes on leukemia risk in multivariate logistic regression analysis, adjusted for sex and age.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.