As expected, higher expression levels of MYC, E2F1, E2F2, and E2F3 showed a trend towards concomitant higher expression levels of most of the analyzed miRNAs, in line with the concept of those genes to represent stimulators of the respective clusters (Figure 4a ).
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Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma - reasons and consequences.
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A similar trend could be shown also for all the residual miRNAs but it did not reach statistical significance (data not shown).