The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.

Although overexpressing LIN-18 ICD at higher doses (40 ng/μl) showed a trend towards exacerbation of 128Q cytotoxicity but did not reach statistical significance relative to control ( Figure S5 ), overexpressing LIN-18 ICD at 40 ng/μl produced cytotoxicity in 19Q nematodes ( Figure S5 ), suggesting that LIN-18 ICD has dose-dependent effects in polyQ; lin-18 nematodes.

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