Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer.

In addition, this correlation was statistically significant for HER2-negative, lower grade, and early stage samples, and it approached significance in advanced stage tumors (p = 0.05).

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Although differences in blood vessel density among the groups were not statistically significant, interestingly we did observe an overall trend of elevated blood vessel density with increased expression of α3 (Figure 3 ).

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Although our analysis detected trends of increased α3 expression in IDC of certain hormone receptor status, these trends did not reach statistical significance in both the AMC samples and the commercial TMA, so their significance remains uncertain.

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