Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.

PLoS Genet · 2014 · PMC4072514 · PMID 24968232

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

did not reach statistical significancep = 1.10×10 −7actually significant

A ) Cis -eQTL SNPs were located nearer H3K4me3 peaks in CD4 T EM cells than the 159 top SNPs that did not reach statistical significance at 5% FDR ( p = 1.10×10 −7 , one-sided Mann-Whitney test).

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nominally significantp <0.05actually significant

In addition, there was substantial enrichment of nominally significant associations ( p <0.05) among disease SNPs.

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failed to reach significanceno p-value reported

One possibility is that some SNPs failed to reach significance threshold due to the small sample size or low expression levels in resting cells.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.