The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120).

However, unlike in the β-arrestin-2 interaction assay where the effect of these mutants did not reach statistical significance, in the Ca 2+ assay both N215A 5.46 ( p < 0.05) and T119A 3.33 ( p < 0.001) produced significant reductions in potency for GW9508 compared with wild type FFA4.

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Finally, it was also interesting to note that there was a clear trend among the four FFA4 agonists tested across all mutations in that the more potent ligands tended to be affected by more mutations.

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