Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index.

After adjustment for average BMI, no associations retained statistical significance, but multiple phenotypes approached significance including T2D, NAFLD, and the protective effect on fibrocystic breast disease.

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Significance corrections like Bonferroni may be too strict; some of the near-significant pleiotropic associations may, in fact, represent genuine associations.

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