Unconventional maturation of dendritic cells induced by particles from the laminated layer of larval Echinococcus granulosus.

As the sole stimulus, pLL gave rise to a nonsignificant trend toward an increase in the number and percentage of peritoneal DCs after 18 h; together with LPS, it did not alter the decrease in DC numbers and percentages caused by this inflammatory stimulus (data not shown).

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Disulfide reduction significantly diminished the capacity of pLL to potentiate IL-10 and inhibit IL-12/23p40; it also gave rise to a clear trend toward diminished capacities to induce CD86 and to inhibit CD40 upregulation ( Fig. 10 ).

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This treatment caused a trend toward lower capacity to potentiate IL-10, which did not reach statistical significance, and it did not affect the capacity to inhibit IL-12/23p40 (data not shown; see Fig.

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