Comparison and optimization of hiPSC forebrain cortical differentiation protocols.

PLoS One · 2014 · PMC4148335 · PMID 25165848

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did not reach statistical significanceno p-value reported

Both sizes of AggreWell aggregates were significantly larger than manually formed aggregates, and although there was a trend for an increased aggregate diameter between 3,000 and 8,000 cells/aggregate, it did not reach statistical significance.

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showed a trendno p-value reported

Differentiation of monolayer-maintained NPCs from two subsequent passages showed a trend for decreased MAP2 mRNA expression after the first passage and significantly lower MAP2 expression after the second passage compared to neurons derived directly from day 24 aggregates ( Fig. 6B ).

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did not achieve significanceno p-value reported

There was also a trend for increased expression of pluripotent cell markers NANOG and Oct4 ( POU5F1 ), but this did not achieve significance.

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