Plasma homocysteine and genetic variants of homocysteine metabolism enzymes in patients from central Greece with primary open-angle glaucoma and pseudoexfoliation glaucoma.

The minor allele of MTHFD1 rs8006686 showed a trend for increased risk of both POAG and PXFG ( P >0.05).

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In a study by Fan et al the rs8006686 polymorphism showed a marginally significant association with PXFG, but this finding was not stable after correction for multiple comparisons. 23 Materials and methods This was a prospective, case-control association study that assessed plasma homocysteine levels and genetic variants of homocysteine metabolism enzymes in a cohort of Greek patients with either POAG or PXFG as compared with controls.

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Results Homocysteine levels were slightly higher in the patient group (POAG and PXFG) compared with controls, but the difference did not reach statistical significance.

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