Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor.

At day 4 p.i., all three treatment groups (zanamivir and celecoxib combination, zanamivir alone or celecoxib alone group) showed a trend of reduction in the pulmonary levels of proinflammatory cytokine IL-6, IL-1β and RANTES although this reduction was not statistically significant ( Fig. 7a ).

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However, the difference in COX-2 mRNA levels between CK1 and AH1-infected samples did not reach statistical significance.

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