Loss of the endothelial glucocorticoid receptor prevents the therapeutic protection afforded by dexamethasone after LPS.

As was previously observed in other experiments [9] , there was a strong trend towards baseline mean arterial pressure (MAP) being slightly elevated in GR EC KO mice compared to controls (78.4±0.73 mm Hg vs. 73.1±1.91 mm Hg, p = 0.05).

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There was a trend towards increased expression of GRβ after GR siRNA and DEX treatment though this did not reach statistical significance.

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