Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.

Although 5αR1 protein levels were increased in those samples with the highest NASs and those with evidence of hepatocyte ballooning, these failed to reach statistical significance ( Figure 1 , C–E).

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The degree of lobular inflammation was also higher in the 5αR1 −/− mice but did not reach statistical significance ( Figure 3 B).

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