A pooled analysis of several single-arm clinical studies found that dasatinib efficacy and safety profiles were similar in Asian and non-Asian patients with CML (all phases), although among patients with CML-CP, Asian patients showed a trend toward higher response rates compared with non-Asians [ 5 ].
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Efficacy and safety of dasatinib versus imatinib in the East Asian subpopulation of the DASISION trial of newly diagnosed chronic myeloid leukemia in chronic phase.
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Compared to non-East Asian patients, East Asian patients may have higher exposure to dasatinib based on steady-state AUC, C min and C max trends, but this did not reach statistical significance.