Noninvasive molecular imaging of cell death in myocardial infarction using 111In-GSAO.

The 111 In-GSAO uptake in the infarct zone was higher than 99m Tc-AA5 uptake, although the results did not reach statistical significance, due to the small sample size (1.10 ± 0.45%ID/g vs 0.47 ± 0.23%, P = 0.47).

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Moreover, when compared with uptake at 2 weeks post-MI, 111 In-GSAO uptake showed a trend of decline at 4 weeks (n = 6, infarct 0.28 ± 0.09%ID/g, P = 1.0; remote 0.22 ± 0.04%ID/g, P = 1.0, Fig 6 ) and 12 weeks (n = 8, infarct: 0.19 ± 0.07%ID/g, P = 0.332; remote: 0.15% ± 0.1%ID/g, P = 1.0, Fig 6 ) although differences were not statistically significant.

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