Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.

Even though dramatically increased O -GlcNAc levels were observed (Figure 2 ) immunoblot analyses revealed that Thiamet-G treatment actually slightly increased the total amount of tau (92e) and the extent to which tau was phosphorylated but this did not reach statistical significance.

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We observed a strong trend of less sarkosyl insoluble tau in the 500 mkd Thiamet-G treatment group (32% reduction), which was consistent in magnitude with our earlier JNPL3 study, although this difference did not reach statistical significance in the TAPP mice (Figure 4 ).

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