Oral liarozole in the treatment of patients with moderate/severe lamellar ichthyosis: results of a randomized, double-blind, multinational, placebo-controlled phase II/III trial.

12 , 13 In the comparative study, liarozole was equally as effective as acitretin and showed a trend towards a more favourable tolerability profile. 13 The objective of this study was to demonstrate the efficacy and safety of once-daily oral liarozole, 75 or 150 mg, vs. placebo in the treatment of patients with moderate/severe lamellar ichthyosis.

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Conclusions The primary efficacy variable did not reach statistical significance, possibly owing to the small sample size following premature termination.

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