Absence of chloride intracellular channel 4 (CLIC4) predisposes to acute kidney injury but has minimal impact on recovery.

The differences do not reach the 95% confidence level although the mean and median day 2 BUNs showed a trend toward more severe injury among the Clic4 nulls (WT and KO means 249 mg/dl and 271 mg/dl; medians 260 mg/dl and 325 mg/dl, respectively).

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The median fractional fibrosis was 6.85% and 10.37% for the WT and CLIC4 null mice, respectively, which did not reach statistical significance using Wilcoxon non-parametric testing.

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