Monitoring vigabatrin in head injury patients by cerebral microdialysis: obtaining pharmacokinetic measurements in a neurocritical care setting.

Mean GABA concentration (±SD) increased steadily from 0.27 ± 0.11 μmol l −1 before the first dose to 0.61 ± 0.30 μmol l −1 for the period between the third and fourth doses (Figure 4 A), although this increase and the increases for each inter-dose period did not reach statistical significance (Student's paired t test; P > 0.05).

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The brain microdialysates from TBI patients in the present study showed a trend for increase in GABA concentration from 0.27 to 0.51 μmol l −1 in 24 h, after two VGB doses in four patients ( P = 0.06).

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