Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain.

( 2012 ), we find 450 in the genome in autism; compared to this, four hits in our gene set reflect a nominally significant enrichment (3.6 fold; p = 0.006, Poisson test).

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By further modeling inhibitory gene expression as a linear functions of age in cases and controls in the Chow dataset, we showed a significant trend toward reductions in inhibition with age in cases relative to controls, in keeping with the t -test result.

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