Pre-treatment whole blood gene expression is associated with 14-week response assessed by dynamic contrast enhanced magnetic resonance imaging in infliximab-treated rheumatoid arthritis patients.

PLoS One · 2014 · PMC4264695 · PMID 25504080

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0580

boldest claim

The sentences

nominally significantp<0.01actually significant

For K trans , we defined a 256 gene signature associated with 14-week treatment response by identifying genes with a nominally significant gene expression by treatment interaction term (p<0.01).

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approached significanceP = 0.058so close (0.05 < p ≤ 0.1)

There were no significant differences in any of these characteristics, or in prednisone or NSAID use, between the two arms, although higher RAMRIS-synovitis scores in the infliximab group approached significance ( P = 0.058).

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