Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1.

When the DLB and control cohorts were combined for analysis, an inverse correlation was observed between KLK6 level and α-syn in the cingulate cortex that approached significance (p = 0.06) (Figure 2 e).

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When the DLB and control cohorts were combined for analysis a trend towards an inverse correlation was observed between CAPN1 activity and α-syn in the cingulate (Figure 1 i) and parahippocampal cortex (Figure 1 j) but did not reach statistical significance.

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