The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: the PuLsE (Open Prospective Randomized Long-term Effectiveness) trial.

Epilepsia · 2014 · PMC4283995 · PMID 24754318

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

a nonsignificant trendp = 0.08so close (0.05 < p ≤ 0.1)

When change from baseline AED load was evaluated by MMRM analysis, a nonsignificant trend was observed between the groups (p = 0.08) with a greater increase in the BMP group (means ± standard error (SE): 0.18 ± 0.05) than in the VNS + BMP group (means ± SE: 0.06 ± 0.05) (data not shown).

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showed a trendno p-value reported

Changes in AEP scores, which reflect the burden of AED-related toxicity, showed a trend to have a more favorable course in the VNS + BMP group than in the BMP group.

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failed to reach statistical significanceno p-value reported

Median percent change in seizure frequency from baseline to 12 months confirms an increasing improvement in seizure control for the VNS + BMP group versus the BMP group over time, although differences at individual time points failed to reach statistical significance (Fig. 3 ).

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