Control LNA-treated tumors had larger mean areas of confluent necrosis (22%) as compared to anti-miR-21 LNA‐treated tumors (10%), although this did not reach statistical significance (p = 0.17) ( Fig. 6D ).
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MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor.
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This increase was significant in WM1552c and WM793b (p < 0.05) and approached significance in MEL 39.