Synergistic effects of NOD1 or NOD2 and TLR4 activation on mouse sickness behavior in relation to immune and brain activity markers.

Brain Behav Immun · 2015 · PMC4295938 · PMID 25218901

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

approaching significancep = 0.057so close (0.05 < p ≤ 0.1)

Two-way ANOVA revealed a significant NOD × LPS interaction in the PVN ( F (1,11) = 18.810, p < 0.001), insula ( F (1,13) = 6.940, p < 0.05) and SO ( F (1,13) = 17.496, p ⩽ 0.001) and an interaction approaching significance in the BNSTv ( F (1,15) = 4.257, p = 0.057).

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did not reach statistical significanceno p-value reported

While the effect of FK565 did not reach statistical significance after correcting for multiple testing, LPS diminished food intake 1 day after treatment when compared to VEH.

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