The effects of two polymorphisms on p21cip1 function and their association with Alzheimer's disease in a population of European descent.

Although in the frontal lobe there was a trend for the p21 cip1 variant to be associated with lower synaptic densities and a reduction in the synaptic remodelling activity compared to the common p21 cip1 , the result did not reach statistical significance (data not shown).

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There was a trend for an association between the rare variant and PD with dementia, relative to PD without dementia (age matched subjects), but the result failed to reach statistical significance ( Table 5 ).

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