Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer.

, 14 when we classified patients into percentiles, we observed that patients with low endoxifen concentrations (<14.15 n M ) had higher risk for distant relapse or death compared with those with high concentrations (>35 n M , P =0.03, Figure 5a ), and showed a trend by multivariate Cox regression analysis of an increased hazard ratio (HR) of 1.94; 95% confidence interval (CI) 0.96–3.93; P =0.064 ( Table 4 ).

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There was no association between endoxifen concentrations and DRFS given the lack of a significant trend ( Table 4 , Figure 5a ).

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