Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany.

Among adults, a decreasing trend in meningitis percentage was found in the pre-PCV7 period as well (1992/93-2005/06, slope: −0.32).

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A reduction in PCV7 vaccine serotypes was observed post-PCV7-vaccination in both children and adults but did not reach statistical significance in either category for every single PCV7 serotype.

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For PCV13-non-PCV7 serotypes, there was an increase in the post-PCV7 period when compared to the pre-PCV7 period (reaching statistical significance for children, and near statistical significance for adults), followed by a decrease in children and adults in the post-PCV13 period.

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