TLR4 activation induces IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung.

In both GM lines the levels of IL-18 were reduced but this failed to reach statistical significance (Figure 8 ).

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The levels of IL-1α and IL-1β 6 hours after challenge were not altered in the P2X 7 KO mice; the level of IL-18 did appear to be reduced, although this did not reach statistical significance (Figure 6 ).

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