The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster.

A SNP in Sema-1a (2L.8630728) was very on the brink of significance on the high glucose diet ( p = 1.42 x 10 -6 ) and nowhere near our significance threshold on the low glucose diet ( p = 0.001).

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rettgeri load in flies reared on the low glucose diet ( p = 7.65 x 10 -7 ) and approached significance in flies reared on the high glucose diet ( p = 8.87 x 10 -5 ) and when the data from both diets were combined ( p = 1.49 x 10 -6 ).

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The lines exhibited highly significant genetic variation for all NIs after rearing on either diet ( p < 10 -4 in all cases; Table 2 ).

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[ 44 ] determined that 52% of the lines in the DGRP are infected with Wolbachia , and we find Wolbachia status to be a weakly significant predictor of P . rettgeri load on both diets ( S2 Fig , low glucose: p = 0.0361; high glucose: p = 0.0327; data from both diets combined: p = 0.014), with lower average bacterial loads in the Wolbachia- infected lines than in the Wolbachia- uninfected lines.

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rettgeri load of flies reared on the low glucose diet ( p = 0.45) but was marginally significant when flies were reared on the high glucose diet ( p = 0.07; Fig. 5a ).

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