Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity.

Despite a negative trend, suggesting a small decrease, no significant difference was observed between baseline and final total α-syn (mean difference −190.50 pg/ml, 95% CI −382.57, 1.56, p = 0.052), in subjects meeting Hgb cutoff.

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We hypothesized that this paradoxical observation might depend on disease stage, and separation of two cohorts by stage showed a trend, in both cohorts, toward more positive correlation with increasing severity.

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