Pleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study.

PLoS One · 2015 · PMC4366224 · PMID 25789475

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closest p

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showed a trendno p-value reported

Four other nearby (40–60kb away) but uncorrelated (r 2 with rs12418451 < 0.2) SNPs in this region also showed a trend of stronger effects in males than females, though none suggested a statistically significant difference (p-heterogeneity>0.05, Table 3b ).

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marginally significantno p-value reported

We also observed a marginally significant association with melanoma in TPCN2 , suggesting a potential male-specific pleiotropic association with both melanoma and prostate cancer.

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did not reach statistical significanceno p-value reported

While this latter finding did not reach statistical significance, it is a biologically plausible candidate for follow-up studies.

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