Chromosome substitution strain assessment of a Huntington's disease modifier locus.

We found that, compared to Hdh Q111/+ B6J mice, the percentage of EM48-positive nuclei with intranuclear inclusions was higher in Hdh Q111/+ B6J.AJ10 mice (35.88 ± 11.45 vs 46.69 ± 12.11, respectively), although the difference did not reach statistical significance (Fig. 6 b; p = 0.0694).

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Based on our current data, we would need at least 19 mice per group to detect the small effect of the chr10 A/J variants in the traits approaching significance at 5 months of age (somatic instability in the liver and intranuclear inclusions), perhaps fewer at a more advanced age where each phenotype is more robustly detected (Wheeler et al. 2002 ).

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