Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.

Among 39 polymorphic sites, 20 had significantly lower expression in strains with the insertion, 2 had nominally significant differences in the opposite direction, and 17 were not significantly different.

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In addition, two of three genes for which the congenic experiments showed a trend but did not provide significant support ( Sntg1 and Dph5 ) also showed significant evidence of suppression by the edited allele ( Fig. 6B ).

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