Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGFβ receptor I kinase.

While the 61% increase (from 12.8 to 20.5 cells/mm 2 , p < 0.001) in the number of proliferating cells upon SD-208 treatment in the central region did not reach statistical significance, SD-208 treatment significantly increased the number of proliferating cells by 121% (from 24.7 to 55.2 cells/mm 2 , p < 0.001) in the periphery of the tumour (Figure 6 C).

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In addition, continuous SD-208 treatment resulted in a significant increase of the number of distant metastases 4 weeks after surgical removal and a clear trend for increased metastatic tumour burden (Figure 5 C).

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