HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: results of a randomized phase II exploratory clinical trial.

Retrovirology · 2015 · PMC4414440 · PMID 25924841

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of borderline significanceno p-value reported

Anti-Tat Ab negative vaccinees had a reduction of borderline significance at year 3, possibly explained by the fact that most of these subjects (76%) had Tat-specific cellular responses.

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showed a trendno p-value reported

Further, the 30 μg, 3x vaccine regimen induced the highest HIV-1 DNA decay, however, also the 7.5 μg, 5x showed statistically significant HIV-1 DNA decreases at year 3, whereas the 30 μg, 5x showed a trend only at year 2, whereas no significant changes were observed in 7.5 μg, 3x group (Table 8 ).

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did not reach statistical significanceno p-value reported

This was associated with decreases of naïve and effector memory T cells (Tem), which, however, in most cases did not reach statistical significance (Figure 7 A).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.