Multimodal functional and structural neuroimaging investigation of major depressive disorder following treatment with duloxetine.

There were no main effects of time in the MDD patients, but healthy participants showed a significant decrease with time in response to the mean of medium and high intensity of expressions in the anterior cingulate (x = 9, y = 29, z = 40; 315 voxels, peak T = 4.27; p (FWE corrected) = 0.002) and precentral region (x = −51, y = 11, z = 34; 190 voxels; T = 4.08; p (FWE corrected) = 0.018), as well as approaching significance in the thalamus (x = 3, y = −13, z = 10; 118 voxels; T = 4.12; p (FWE corrected) = 0.070).

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Within the MDD group, a main effect of time was observed in which there was a significant increase in the BOLD response to the mean of the medium and high intensity of expressions in the posterior cingulate/precuneus (x = −3, y = −43, z = 19; 221 voxels; peak T = 4.50; p (FWE corrected) = 0.010), while healthy participants showed a trend towards a decrease in the orbitofrontal region (x = 45,y = 29, z = 11; 118 voxels, T = 4.61, p (FWE corrected) = 0.068).

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