Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.

However, enrichment of human blood expression quantitative trait loci has been established among weakly significant chemotherapeutic drug-susceptibility loci ( Gamazon et al. 2010 ).

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The result was highly significant on a per-chemical basis ( q = 0.0006), and at the significance threshold for the entire combined set of SNPs × chemicals ( q = 0.10).

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Using a standard false-discovery computation, we estimated the proportion of true discoveries for the SNP across the chemicals as 0.25, a significant trend that remained even after removal of the three top MAGWAS-identified chemicals.

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