Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium.

CAR activation by B[a]P approached significance (p-value = 3E-4) when the Hepa1c1c7 cell line was exposed to 5 μM B[a]P for 8 hrs, whereas B[a]P in AhR-null Hepa1c1c7 hepatocytes had no effect on the CAR biomarker signature (from study GSE11796 ) ( Figure 5B , left).

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Two of the 9 biosets from mice exposed to lipopolysaccharide (LPS) showed suppression of CAR, with 3 of the other biosets approaching significance for suppression ( Figure 7B ).

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