The comparison of some clinical characteristics between the patients with different genotypes showed a trend for longer survival of patients with 6A/6A genotype compared to the carriers of 5A allele ( 5A/5A+5A/6A genotypes, p = 0.118, Log rank test).
The conducted univariate and multivariate analyses and survival estimates did not find significant association between the genotypes and clinical, pathological and epidemiological variables.[ 20 ] Analogously, no association was found between the MMP3 -1171 5A > 6A polymorphism and survival of patients with lung cancer from Spain.[ 25 ] In our study, we also did not obtained significant associations of MMP3 -1171insA genotypes with the clinical or demographic melanoma characteristics; however, there was a clear trend for longer survival of the patients with 6A / 6A genotype compared to the carriers of 5A allele genotypes ( 5A / 5A + 5A / 6A ).