Pharmacogenetics of treatment response in psoriatic arthritis.

The presence of the high-affinity FCGR2A - 131H allele in either homo/heterozygous combinations (HH and HR) in PsA patients receiving etanercept showed a strong trend to a higher rate of EULAR response compared with those without a response (93 vs. 67 %; P = 0.034) [ 17 ].

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In another small PsA study ( n = 58), which assessed single-nucleotide polymorphisms (SNPs) at positions −238 (rs361525), −308 and −489 (rs80267959) of the TNF-α gene in response to TNFis, the −489A allele showed a trend of association with PsA response to etanercept (not significant).

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