Identification of the Adapter Molecule MTSS1 as a Potential Oncogene-Specific Tumor Suppressor in Acute Myeloid Leukemia.

Secondly, while analysis of the Flt3-ITD negative patients included in the analysis of Verhaak et al [ 36 ] showed a strong trend for decreased survival of DNMT3B high-expressing AML patients (p = 0.05 each for event-free and overall survival), this was not the case for FLT3-ITD positive patients (not shown).

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Treatment of FLT3-ITD transduced murine 32D cells showed a trend for an upregulation (p = 0.05) of MTSS1 mRNA levels ( Fig 5B ).

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Strikingly, patients with high MTSS1 and low DNMT3B expression showed a highly significant increased overall survival rate compared to those with low MTSS1 and high DNMT3B expression ( Fig 2D ).

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