Although the concentration of urea was elevated in all groups 24 h post-LPS, the increase in TRPV4 KO mice was greatest, whereas that in antagonist-treated mice did not reach statistical significance.
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Blockade or deletion of transient receptor potential vanilloid 4 (TRPV4) is not protective in a murine model of sepsis.
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The sentences
Blood pH was significantly decreased in these mice, and they also showed a trend to elevated blood urea concentration, relative to vehicle-treated WT controls.