Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV.

A strong trend for higher levels of inflammatory cytokines was observed after SmyleDCpp65 administration (IL-4, IL-10, IL-5, IL-6, IL-8, and in particular high levels IFN-γ, GM-CSF, TNF-α, and MCP-1) ( Figure 4b ) ( Supplementary Information, Table S2a ).

also in 5,725 other papers

In contrast, most of the naive CD8 + T cells in spleen corresponded to CD31 + thymic although CD8 + T cells obtained from “4x” SmyleDCpp65 showed a trend towards higher numbers of CD31 − central naive CD8 + T cells ( Figure 6g ).

also in 53,322 other papers

Strikingly, phenotypic analyses of T cells during the immune reconstitution showed that at 10 weeks post-HSCT (just 3 weeks after the first prime boost) of the “4x” cohort, highly significant increases in the frequencies of the EM CD4 + and CD8 + T cells could be detected in peripheral blood.

also in 132,142 other papers