MiRNA-Related SNPs and Risk of Esophageal Adenocarcinoma and Barrett's Esophagus: Post Genome-Wide Association Analysis in the BEACON Consortium.

Three of these five SNPs had been associated with EA ( miR-423 rs6505162, miR-196a-2 rs11614913, and RAN rs14035), while two reached borderline significance ( XPO5 rs11077 and pri-miR-219-1 rs213210).

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When EA and BE cases were combined into a single case group and compared to the same set of controls, all three of these variants were highly-ranked among the set of 31 nominally significant SNPs ( S7 Table ), and two of the three (rs7526812 T>C, rs12534337 G>A) had smaller P values than observed in the individual analyses, without reaching Bonferroni or FDR significance thresholds. rs1644730 T>A is located within a predicted miR-630 binding site in the 3’UTR of all-trans-retinol dehydrogenase 8 ( RDH8 ), which encodes a short-chain dehydrogenase/reductase enzyme involved in rhodopsin regeneration in the vision pathway.

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