Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression.

Correlating miR-137 expression with patient survival demonstrated that patients with decreased miR-137 had an increased hazard of death (HR = 0.61) as compared to patients with no change or increased expression of miR-137, although this did not reach statistical significance ( P = .269) (Figure 6F ).

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The expression of miR-137 did not statistically correlate with MSI1 expression in tissue samples ( P = 0.54, Supplemental Table 6 ), although a clear trend is revealed in our patient data analysis and provides important precedence that analyzing more patients for the expression of MSI1 and miR-137 is needed in order to obtain statistical significance.

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