Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine.

Notably, plasmablasts from the Advax 10mg group had a highly significant ~5-fold upregulation of AID expression (p = 0.001) when compared to the TIV alone group ( Fig 5A ).

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Plasmablast generation in the Advax 10mg group (mean area 5.44, SD 3.09) also had a higher point estimate but this did not reach statistical significance when compared to the TIV alone group (p = 0.12).

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Given the limited sample size, the confidence intervals in seroprotection and seroconversion rates overlapped between groups in the sub-study, however point estimates showed a clear trend towards higher antibody titer increases in the Advax-adjuvanted groups, with the Advax 10mg dose group achieving the highest point estimates across all three vaccine strains for seroconversion, seroprotection and GMT fold increases across the vaccine strains ( Table 2 ), and it is noted that H1 A/Cal and B/Bris showed more advantage.

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