Characterization of the Hypothalamic-Pituitary-Adrenal-Axis in Familial Longevity under Resting Conditions.

PLoS One · 2015 · PMC4508039 · PMID 26193655

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borderline non-significantno p-value reported

Modest, sex-specific differences between groups included the trend towards a higher mean 24h ACTH in female offspring, and in males a significantly higher basal ACTH secretion in offspring and a borderline non-significant lower recovery EC 50 in the endogenous ACTH-cortisol dose-response relationship.

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did not reach statistical significanceno p-value reported

When basal ACTH secretion was measured over 3 different time periods (0900–1700 h, 1700–2400 h and 2400–0800 h), it tended to be higher in male offspring, but did not reach statistical significance in one of the three time periods ( S1 Table ).

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