Damage/Danger Associated Molecular Patterns (DAMPs) Modulate Chlamydia pecorum and C. trachomatis Serovar E Inclusion Development In Vitro.

In the presence of apyrase, exposure to exogenous ATP reduced inclusion size compared to mock treated controls, but this reduction did not reach statistical significance, in contrast to exposure to ATP alone.

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pecorum inclusion was reduced to 19.1% of control with the addition of cAMP, 16.9% of control with the addition of ATP, and 64% of control with the addition of EHNA/ADO, although the reduction caused by EHNA/ADO failed to reach statistical significance ( Fig 6A ).

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